SAMe may boost production of neurotransmitters that regulate mood. Taking SAMe seems to reduce symptoms of depression. Several studies have shown that SAMe works and might be as effective as tricyclic antidepressants. Some research also shows that taking SAMe might be helpful for people who do not have a good response to a prescription antidepressant.

Needs: folic acid, B6, and B12

Dose: Effective dosage is 400–1600 mg per day. I feel effects taking one 1000 mg tablet when waking. Take it with a multivitamin that provides: 400 mcg of folic acid, at least 50 mg of vitamin B6, and 50 mcg of B12 (along with the rest of the B-complex).